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The History of Alchemy
It used to be thought that alchemy, which picked up strikingly in the 16th century, 1500s in thereabouts, was a sort of mystical procedure involving all sorts of strange notions and so on. And that's not entirely untrue, but it is substantially untrue in that all chemists were engaged in what was known as chrysopoia. That is looking for ways to transform invaluable materials into valuable ones. In the process of doing so or attempting to do so, they learned how to create complex amalgams of various kinds.