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Ep. 68: “Blood Transfusions” Featuring Dr. David Gibb

The Immunology Podcast

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Exploring Immune Dynamics and Aging

This chapter examines research on NOD1's role in lymphopoiesis and its interaction with the STAT5 signaling pathway, emphasizing immune cell generation independent of microbes. It further discusses age-related changes in T cell populations, highlighting a decrease in naive T cells and shifts towards a TH2 phenotype in older adults. The chapter also touches on the role of microglia in cancer metastasis and their unique immune functions, challenging existing perceptions of macrophages in the tumor microenvironment.

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