The Biology of Insulin Resistance

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The biology of insulin resistance is mitochondrial malfunction and oxidative stress. Mitochondria are the organelles that live in your cells, they're essential for homeostasis but can also be linked to inflammation. When you have dysfunction in mitochondria, what this leads to is an increase in the fat accumulation in the muscle cells or in the liver cells wherever you find mitochondria.

In today’s solo episode and I’ll be talking about insulin resistance, how this impacts your risk of disease and why insulin resistance could drive many chronic conditions and why certain lifestyle measures work for improving metabolic health.

By the end of the episode you will understand:

The relationship between IR and disease

The importance of sugar balance in the body

What insulin is and how insulin works

What happens when we become resistant to insulin

What are the causes of IR

What we can do to become more insulin sensitive and ultimately prevent disease

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References:

4 grams of glucose - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636990/

IR Overview - https://www.ncbi.nlm.nih.gov/books/NBK507839/

Insulin resistance Mechanisms - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831809/

Insulin resistance, genes and mitochondria - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341556/

Obesity Insulin and cancer - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214048/

Insulin resistance from euglycaemic clamps - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379600/

Sleep debt and Insulin resistance - https://pubmed.ncbi.nlm.nih.gov/10543671/

Increased snacking with poor sleep - https://pubmed.ncbi.nlm.nih.gov/19056602/