A new research paper was published in Oncotarget's Volume 13 on September 28, 2022, entitled, “Genomic alterations predictive of poor clinical outcomes in pan-cancer.”
Genomic alterations are highly frequent across cancers, but their prognostic impact is not well characterized in pan-cancer cohorts.
In this new study, researchers Crystal S. Seldon, Karthik Meiyappan, Hannah Hoffman, Jimmy A. Guo, Neha Goel, William L. Hwang, Paul L. Nguyen, Brandon A. Mahal, and Mohammed Alshalalfa from the University of Miami, Massachusetts General Hospital, Broad Institute of MIT, University of California San Francisco, and Dana-Farber Cancer Institute and Brigham and Women’s Hospital used pan-cancer cohorts from The Cancer Genome Atlas (TCGA) and the MSK-IMPACT study to evaluate the associations of common genomic alterations with poor clinical outcome.
“There is growing interest in genomic profiling (i.e. tumor mutations, copy number (CN) alterations) for cancer therapy and precision oncology to inform treatment decisions and identify patients for relevant clinical trials [1].”
Full press release - https://www.oncotarget.net/2022/10/04/oncotarget-genomic-alterations-predictive-of-poor-clinical-outcomes-in-pan-cancer/
DOI: https://doi.org/10.18632/oncotarget.28276
Correspondence to: Mohammed Alshalalfa - mohamed.alshalalfa@gmail.com
Keywords: genomic alterations, TP53, TCGA, poor prognosis
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