Epigenetic remodeling during chronic overnutrition

Why is it so hard to lose weight—and even harder to keep it off?

In this episode, we explore groundbreaking research showing that fat cells can retain an epigenetic "memory" of obesity, even after significant weight loss. This emerging science helps explain why weight regain is so common and why willpower alone is not the issue.

We're joined by Ferdinand von Meyenn, Assistant Professor at ETH Zurich, where he leads research on nutrition and metabolic epigenetics. Prof. von Meyenn has published over 60 peer-reviewed papers, with work featured in top scientific journals including Nature and Cell.

Together, we unpack what "obesogenic memory" really means, how epigenetics allows fat cells to adapt—and remember—past environments, and why long-term exposure to excess calories can biologically prime the body to regain weight faster in the future.

In this conversation, you'll learn:

• What epigenetics is and how it differs from genetics
• How fat cells adapt to chronic overnutrition—and why those changes can persist after weight loss
• Why short-term weight changes are easier to reverse than long-term weight gain
• How this research challenges the idea that weight regain is a personal failure
• What current data suggests about bariatric surgery, GLP-1 medications, and long-term outcomes
• The role of inflammation, adipose tissue signaling, and the brain in body-weight regulation
• Why prevention matters—and why compassion matters even more for those already affected
• What researchers hope to uncover next about rewriting epigenetic memory

This episode offers a powerful, science-based reframe: difficulty maintaining weight loss is not about weakness—it's about biology adapting to past environments. Understanding this may open the door to more effective, humane, and sustainable approaches to metabolic health in the future.

🎧 Whether you're a clinician, researcher, or someone who has lived through the frustration of weight regain, this conversation brings clarity, validation, and a forward-looking perspective on where the science is headed.

If you found this episode helpful, consider subscribing on YouTube and sharing it with someone who could use a science-grounded reminder that their struggle is not a moral failing.

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The content of our show is educational only. It does not supplement or supersede your healthcare provider's professional relationship and direction. Always seek the advice of your physician or other qualified mental health providers with any questions you may have regarding a medical condition, substance use disorder, or mental health concern.