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The Darwinian Idea of Survival of the Fittest
The black plague and other pathogens have killed so many people. And you mentioned that those who survived had genes that gave them a stronger immune response or boost when faced with this pathogen. It seems like actually it comes down to immunity instead of being a tough guy, at least at the macro scale. Although we're fit to fight diseases in many ways, we're less kind of well functioning human human beings.