TWiV 1203: What's old is flu again
This Week in Virology
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The Intricacies of Immune Responses to Vaccines
This chapter explores the complexities of the immune system's response to vaccines, contrasting de novo responses in naive individuals with the reuse of pre-existing strategies in those who have encountered related pathogens. It highlights the roles of public and private clonotypes in antibody formation, as well as the impact of DNA versus protein vaccines on immune repertoire diversity. Additionally, the chapter delves into antigen imprinting, immune memory, and the nuances of B cell responses, emphasizing how prior infections shape the capabilities of vaccines and the dynamics of immune responses over time.
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