How Viagra exploits NO signalling

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Lou Ignarro went from building pipe bombs as a curious teen to winning the Nobel Prize for discovering how a gas—nitric oxide—regulates blood flow, fuels Viagra, and revolutionized cardiovascular medicine. In this explosive conversation, we trace how one molecule transformed sex, science, and the story of human health.

Key Takeaways:

• 00:00 Intro 

• 00:55 The molecule that saves and kills 

• 04:00 The invention of the X-ray

• 05:44 Nitroglycerin: explosive or life-saving drug? 

• 11:07 Fine-tuning and Lou’s religious beliefs 

• 14:38 Judging a book by its cover 

• 16:56 The importance of curiosity 

• 20:00 Thoughts on the Nobel Prize

• 24:58 What does Viagra do and how does it work? 

• 32:10 The importance of collaboration in scientific research 

• 35:15 Achieving the breakthrough discovery 

• 41:02 What happens if a woman takes viagra?

• 42:55 Other applications of nitric oxide 

• 47:57 Lou’s heart-healthy diet 

• 52:41 Outro

Additional resources: 

➡️ Follow Lou Ignarro: 

✖️ Twitter: https://x.com/drignarro 

📚 Dr. NO by Lou Ignarro: https://a.co/d/gSarIKX 

➡️ My new book:

📖 Into the Impossible Volume 2: Focus Like a Nobel Prize Winner: Lessons from Laureates to Concentrate Your Creativity and Ignite Your Career: https://a.co/d/hi50U9U 

➡️ Follow me on your fav platforms:

✖️ Twitter: https://twitter.com/DrBrianKeating 

🔔 YouTube: https://www.youtube.com/DrBrianKeating?sub_confirmation=1 

📝 Join my mailing list: https://briankeating.com/list 

✍️ Check out my blog: https://briankeating.com/cosmic-musings/ 

🎙️ Follow my podcast: https://briankeating.com/podcast 

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Into the Impossible with Brian Keating is a podcast dedicated to all those who want to explore the universe within and beyond the known.

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