The Opposite of CRISPR

In the 1980s when people were discovering these catalytic RNA there was a tremendous excitement about being able to have something not found in nature. Now you know if you look back I mean we're now a few decades ahead and it hasn't been that easy to really do a lot of engineering on ribosines. With CRISPR it's kind of the opposite in a way in the sense that we see a large number of very diverse forms of CRISPR cast proteins, which is consistent with the idea that we find in the lab Nature has also found this to be a very pliable platform for manipulating DNA or in some cases RNA and cells.