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Ep. 27: “AAI 2022: Building on the Past to Meet the Moment” Featuring Dr. Gary Koretzky

The Immunology Podcast

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Exploring the Role of CD20 Positive T Cells in Multiple Sclerosis

The chapter focuses on a study examining the involvement of CD20 positive T cells in CNS-directed autoimmunity, particularly in diseases like multiple sclerosis. It discusses how these T cells acquire CD20 from B cells through trogocytosis, their pro-inflammatory nature, and the potential implications for treating MS. Additionally, the chapter explores the importance of extracellular matrix in tissue regeneration, the role of neutrophils in facilitating wound healing through extracellular matrix movement, and research on spinal microglia population contributing to neuropathic pain and pain recovery mechanisms.

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