
Immune 56: Flip flops on the thymic beach with Al Singer
Immune
The Scurfy Mutation in the Flipflop Mouse
In a normal mouse, you get an otimune disease because you no longer have functional regulatory ta cells. The flipflop mouse also died in three or four weeks if it didn't have these tea cells. I was surprised by that. What we thought we now, what we thought we knew about the importance of class one and class two and ct four and set eight, i think a lot of it is not true. But really it comes down to almost a computer wright. It's either on or off. And is not as much distinction as one would have thought. We've got many, many different binaries, because woe've got a binary ide different signalling molecules or
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