3min chapter

The Life Scientific cover image

Sir Martin Landray on saving over a million lives

The Life Scientific

CHAPTER

The Fundamental Principles of Large Scale Drug Trials

In the past 25 years, clinical trials have become more and more complex. But why on 15 % of these drugs have gone through these clinical trials? Well, martin, having realized that treatments already in use often lacked a good evidence base, you decided to change things. The principles are quite simple really. What we're trying to do is work out whether, when we give a drug or we don't give a drug, which one's better. So that requires something called randamization. Let's think of it as a coin toss. And so actually use the coin toss essentially. If it comes down heads, i the people get aspirin. Now if it comes down tails, they

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