
a16z Bio + Health #8: How to Innovate within Biopharma with Jay Bradner
a16z Live
I'm Crazy About Molecular Glues
I'm crazy about the idea of molecular glues. I think target approaching degradation is, you know, the one such exemplification. Our ship two programme is an intra molecular glue that locks the repressive s h two domains down on to the ship to tyracene phosphotae domain in the active sit through a cryptic channel and an alosteric juncture between the three domains. It's just unprecedented mode of inhibition, and a first ever inhibitor of a pospite.
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