050CE: Specimen Issues and Serologic Testing with Sue Johnson
Blood Bank Guy Essentials Podcast
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Double Dose Antibody Screening
When we talk about double dose, the fact that those cells will have the strongest expression of the antigen or they've inherited two genes that will code for the same thing. The reason we want that is because if my patient makes an anti-JKA, it could be weak. We also know that those are the antibodies that will fall below the level of detection. It's really difficult to find a donor or two or three donors that would have the perfect match where every single antigen is expressed in double dose.
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