Hydroxyurea for secondary stroke prevention in SCD, mutant CALR as a rogue cytokine in MPNs, and parsing pathobiology in Burkitt lymphoma
Blood Podcast
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Children With Sickle Cell Anemia - A Randomized Controlled Trial
The trial looked at overt clinical neurological events in death, but not other acute and chronic complications of sickle cell anemia. The cost-effectiveness argument for low-dose therapy might or might not hold up if moderate dose therapy ameliorates the disease in other ways. Overcoming barriers to optimal care is not easy in Sub-Saharan Africa,. But it's been done in the setting of HIV, malaria, and tuberculosis.
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