Recombination and DNA Repair

Jennifer Doudna changed the world. She didn’t do it intentionally. She pursued her curiosity about the structure and functioning of RNA as a research scientist, one who had been trained by some of the most impactful geneticists at the time, including two Nobel laureates. In the process, however, she and her collaborators discovered a genetic tool that has dwarfed all others for its potential to change both the human condition, but also what it may mean to be human. I am referring of course to CRISPR, the tool that Jennifer Doudna and Emmanuelle Charpentier helped develop and for which they were awarded the Nobel Prize.

In our in-depth conversation we covered the scientific origins of Jennifer’s discoveries, and some of their possible implications. In a time when there is a misplaced notion that support for scientific research needs to be applied directly for certain goal-oriented activities, it is refreshing to have such a clear example of the benefits of fundamental research for our society, along with the need to prepare our minds for the possibilities of the future. It is exactly what the Origins Podcast, and the Origins Project Foundation are designed to highlight—the joy, benefits, and challenges of human intellectual inquiry for our society and our future. It was a pleasure and privilege to spend 90 minutes discussing these issues with this world-renowned biochemist and advocate for science.

Our conversation was both a tutorial about modern genetics, and also an opportunity to discuss issues that society as a whole will have address as we come to grips with the new power of science in this century. With great power comes great responsibility, and I hope discussions such as the one I had with Jennifer will provoke and enlighten. Enjoy.

As always, an ad-free video version of this podcast is also available to paid Critical Mass subscribers. Your subscriptions support the non-profit Origins Project Foundation, which produces the podcast. The audio version is available free on the Critical Mass site and on all podcast sites, and the video version will also be available on the Origins Project YouTube.