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#213 - Uric acid is a key cause of weight gain & fat production | Dr. David Perlmutter & Dr. Casey Means - (Replay)

LEVELS – A Whole New Level

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The Role of Glucose in Insulin Resistance

Dr. Perlmutter: Glucose stimulates insulin repeatedly, which then causes the cell to become a quote unquote numb to it and then we get insulin resistant. We know that based upon interventional trials that can inhibit this pathway at multiple places,. like inhibiting fructose kinase or inhibiting uric acid production by giving people alopurinol in research setting. So- How do you see that these two different mechanisms kind of relatively contributing to the problem of insulin resistance?

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