
The Injectable L-Carnitine Deep Dive
The Hunter Williams Podcast
What Is L‑Carnitine and Why Use Injectable Form?
Hunter explains L‑carnitine's role in energy metabolism and why injections have higher bioavailability than oral forms.
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In this video I do a full deep dive on injectable L-carnitine—what it is, how it actually works in your body, and how I personally use it in my own optimization routine. I’ve been using injectable L-carnitine for years, and the longer I use it, the more it’s become one of those quiet, reliable staples I always come back to for energy, performance, and longevity support.
I start by breaking down the basics: L-carnitine is a naturally occurring amino acid derivative that shuttles long-chain fatty acids into the mitochondria so they can be burned for energy. When you think L-carnitine, think mitochondria, ATP, and better fuel utilization. I explain why injectable L-carnitine is so powerful compared to oral—much higher bioavailability, higher plasma levels, and you avoid some of the downsides like elevated TMAO that can show up with long-term, high-dose oral use.
From there, I walk through the human data: improved exercise performance, reduced lactate, better recovery, cardiovascular support, and even a wild study in centenarians showing more muscle, less fat, and better physical function from L-carnitine supplementation. I also talk about cognitive and mood benefits, and why I stack injectable L-carnitine with acetyl-L-carnitine orally for brain health.
I’m honest about side effects and trade-offs: post-injection pain, occasional lumps, and even the “fishy odor” some people notice at higher doses. I share exactly how I dose it (usually 400–500 mg IM before workouts, three to four times per week), why I prefer intramuscular over subcutaneous, and what needle size works best in the real world.
I close by making the case that injectable L-carnitine isn’t a magic fat burner—but it is one of the most useful, versatile tools for anyone who cares about performance, energy, and long-term health.


