How Do I Manage My Anxiety?

As i've gotten older and as life has gotten more complex with more responsibilities, my base level of anxiety has just shifted up. And for me, it's three things, my work, my relationship and my health. The thing that ties these three themes together is that they are really rtant to me but also ambiguous. It takes a ton of effort to answer these unanswerable questions. So the real question is, what do i do with this?