Is Metformin Really Dangerous, Little-Known Peptides For Muscle Gain & Fat Loss, Testosterone Replacement Therapy & Much More!
Boundless Life
Misconceptions About Testosterone Replacement Therapy
This chapter discusses concerns and misconceptions about testosterone replacement therapy (TRT) and its effects on prostate and cardiovascular health. It clarifies that the risks associated with TRT are more related to overall health condition rather than testosterone's mechanism of action. It also highlights the potential cardio protective effects of therapeutic testosterone.
I answer all these questions and many more in this podcast with Jay Campbell, a Champion Men’s Physique Competitor and the best selling author of the Testosterone Optimization Bible and of The Definitive Testosterone Replacement Therapy Manual: How to Optimize Your Testosterone for Lifelong Health and Happiness... (along with a host of other books linked to in the resources section below).
As a 17 year TRT patient, Jay is a master at manipulating and tweaking the human endocrine system to optimize performance and health. He has experience working with thousands of men and women in optimizing their nutrition, exercise, fitness and fat loss. Jay makes it his personal mission to affect positive and rapid change in each and every client who enters the mastermind program.
During our absolutely epic discussion, you'll discover: -Jay's daily routine and why he eats only 3 days per week...- Metformin
- Armour Desiccated Thyroid
- Lion's Mane
- Curcumin, turmeric,
- Protein powder, MCT oil
- Practice intermittent fasting if you're not fast-adapted or want to lose weight
- The cold-filtration whey isolate Jay recommends...
- 70% of people have some sort of response (allergic or otherwise) to whey protein
- True Nutrition
- Ben has used Mt. Capra
- Cold filtration similar to micro-filtration for wine
- Thorne Mediclear
- Mitochondrial dysfunction
- 2 studies by Dr. Chandler Mars
- Morbidly obese diabetics using a disproportionate amount of Metformin
- "Life extension dose" varies due to body size, ancestry, etc.
- Jay has used Metformin for 17 years
- Lactic Acidosis: studies done on samples not representative of the population
- Gastric issues are a result of Metformin cleaning up microbiota
- Subsides as the biome becomes used to Metformin
- Metformin protects the brain and cleans vascular pathways
- Tell your doctor you want it because it's cardio-protective, prevents cancer and is believed to stop the progress of neuro-degenerative diseases such as Alzheimers
- It's also very affordable
- inhousepharmacy.vu
- Berberine is similar to Metformin, but isn't as regulated and is much more expensive
- Berberine doesn't have a good reputation among people in the know
- Metformin is the most studied drug in the world (because of diabetes)
- Peptides are a great option for an aging man or woman to slow down aging process, increase sleep, etc.
- Ipamorelin (GHRP)
- Highest efficacy if combined with a growth hormone
- Best peptide for women by far
- Neanderthal genes
- Quercetin
- Tesamorelin
- FDA approved; created by Merck
- Created for HIV positive men for lipo dystrophy
- Extremely expensive
- Highly effective in eliminating body fat
- Peptide fact sheet from Tailor Made Compounding
- Sermorelin is useless
- PeptideSciences
- Semax as a nootropic
- BP 157
- Jay doesn't like:
- Ibutamoren
- GHRP 2 or 6
- Thyroid synergistic with hormones and testosterone
- Desiccated Thyroid: Combo of T3 and T4
- Is there a risk of cardio vascular health if one supplements their testosterone?
- If a man is a "metabolic emergency," potential for an incident; because of that person's compromised health
- Testosterone is cardio protective; beneficial for the heart for someone in good health
- TRT as a nootropic
- Testosterone increases dopamine signaling
- Feeling of "well-being"
- Improves working memory
- Once you start using it, do you have to be on it for life?
- Yes, but the individual's environment is vital
- What's the best delivery mechanism?
- Transscrotal application (absorbed 8x better in the scrotum skin)
- What are you taking with testosterone to mitigate the downstream side effects?
- World Link Medical
- You need testosterone to aromatize into estrogen to confer the protective effects to your biological system
- You'd never want to take an aromatase inhibitor
- What should you be looking for in reference ranges, and what should you be monitoring when you're on testosterone?
-Jay's recent roundtable on peptides
-Jay's book: "Guaranteed Shredded"
-Men's Health Optimization Bundle
-Jay's Facebook video about metformin
-My article on the dangers of metformin
-Jay's article on the benefits of metformin
-Jay's Facebook video on metformin
-Metformin Alters Microbiota, Improving Insulin Sensitivity
-Extended release metformin from Inhouse pharmacy
-T.S. Wiley's book: Lights Out - Sleep, Sex & Survival
-My podcast on testosterone optimization from A4M in Vegas
-2020 A4M in Vegas
-Ben's peptide article: How To Use Growth Hormone Stacks For A Better Body: Everything You Need To Know About IGF-LR3, GHRP, and GHRH Peptide Stacks.
-Peptide fact sheet from Tailor Made Compounding
-Ben's article "Should You Get Growth Hormone Injections (And Will GH or IGF-1 Increase Your Cancer Risk)?"
-Dr. Seed's oral BPC-157 (use ode BEN for 15% off entire product line)
-Amazon version of the Testosterone Optimization Bible
-Pharmacokinetics of testosterone cream applied to scrotal skin.
-Zach Bush's Restore
Other notes from Jay:
-Metformin Study: Mitochondrial Dysfunction
-This was on a thoroughly compromised patient population group of Morbidly Obese Diabetics who were using anywhere from 6-9 grams of Metformin per day. If you do further searches, it’s actually the opposite. Metformin reverses Mitochondrial Dysfunction. There are many, many others.
-Metformin Study: Lactic Acidosis - The fear of this condition happening was based on a study from the 40s (still attempting to find it) also in a massively compromised patient cohort. These patients were in end-stage renal failure and also obese and diabetic.
We must be mindful that correlation does not equate to causation. All of these linked studies show that Lactic Acidosis rarely happens if ever in normal patients population groups. Check them here, here and here.
Elevated plasma metformin concentrations (as occur in individuals with renal impairment) and a secondary event or condition that further disrupts lactate production or clearance (e.g., cirrhosis, sepsis, or hypoperfusion), are typically necessary to cause metformin-associated lactic acidosis (MALA). As these secondary events may be unpredictable and the mortality rate for MALA approaches 50%, metformin has been contraindicated in moderate and severe renal impairment since its FDA approval in patients with normal renal function or mild renal insufficiency to minimize the potential for toxic metformin levels and MALA. However, the reported incidence of lactic acidosis in clinical practice has proved to be very low (
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