For nearly a century, scientists believed we had discovered ALL of the essential fatty acids the human body needs. But what if they were wrong?

Stephanie Venn-Watson, a veterinary epidemiologist and longevity researcher, joins Dave to reveal a groundbreaking discovery—a newly identified essential fatty acid, C15, that may hold the key to healthier aging and even longer lifespans. Originally uncovered in an unlikely place—U.S. Navy dolphins that were outliving their wild counterparts by decades—this forgotten fat is now shaking up the scientific community.

So why hasn’t anyone told you about it?? Decades of misguided dietary advice stripped this crucial nutrient from our food system, leaving an entire generation unknowingly deficient. Even worse, pregnant women have been some of the MOST hurt from this cruel change to our modern diet. Now, cutting-edge research is proving that C15 plays a critical role in cellular stability, mitochondrial function, and total mental health.

What You’ll Learn in This Episode:

• The first new essential fatty acid discovered in nearly 100 years—and why it matters

• How dolphins led to one of the BIGGEST breakthroughs in human nutrition

• Why the removal of C15 from our diets is accelerating aging

• The surprising connection between C15 and mental health

• How this “missing” fat could outperform some of the biggest longevity drugs today!

• What foods naturally contain C15—and should you supplement it?

*** Get 15$ off Fatty15 at www.fatty15.com with code: DAVE ***

SPONSORS

Puori | Visit https://puori.com/dave and use code DAVE for 20% off.

Calroy | Head to https://calroy.com/dave for an exclusive discount.

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Fatty15 Instagram – https://www.instagram.com/fatty15/

• Fatty15 Website: www.fatty15.com

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

00:00 – Intro

00:34 – Meet Dr. Stephanie Venn-Watson

00:46 – Discovering C15 in Navy Dolphins

01:58 – Challenges and Skepticism

04:21 – Scientific Validation and Research

06:59 – C15’s Impact on Human Health

27:43 – Big Data, AI, and Longevity Research

36:08 – C15 as a Longevity Nutrient

42:14 – The Navy’s Role in Fatty 15

43:03 – Epigenetic Aging and Lifespan

44:51 – Nutritional Guidelines and C15 Deficiency

50:41 – Mental Health and Endocannabinoids

51:33 – Dairy, Fats, and Nutrition History

56:38 – Fatty 15 in Skincare and Supplements

01:03:58 – Regulatory Changes in Nutrition

01:11:26 – Gender Differences in Fatty Acids

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Ep: 385 Matt & Dave Catch Up

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