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S6.11: Meet the DNA Detectives hunting the causes of cancer

Genetics Unzipped

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The Role of Apobex in Cancer

By 2021, the team had analysed DNA from more than 500 samples of saucygeal cancer from eight countries. Curiously, they found that the mutational fingerprints were similar across all countries studied. Damage inflicted by Apobex accounted for around a quarter of all the mutations in each saucy geal cancer on average. Unfortunately this research is coming too late to help Emily's parents, lying in their hillside graves. But Diana Menya is hopeful that her work will save lives in the future. She's also optimistic that the project will pick apart the roles of nature and nurture in causing Kenya's esophageal cancer epidemic.

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