Mitochondria: Key to Health and Longevity

This chapter explores the essential roles of mitophagy and autophagy in maintaining cellular health and their connection to dietary practices like fasting and calorie restriction. It emphasizes the intricate relationship between mitochondrial function, glucose levels, and mental health, challenging notions about diet and obesity. By examining the genetic and lifestyle influences on mitochondrial health, it reveals the complexity behind metabolic and mental well-being.

Transcript

chevron_right

Play full episode

chevron_right

Transcript

Episode notes

My guest this episode is Chris Palmer, M.D., a board-certified psychiatrist and assistant professor of psychiatry at Harvard Medical School. He explains the important connection between nutrition, metabolism and mental health and his pioneering work using the ketogenic diet to successfully treat patients with various mental illnesses, including depression and schizophrenia. Dr. Palmer explains how the ketogenic diet is an evidenced-based treatment for epilepsy, mimics the fasted state and can offset the cognitive decline in Alzheimer’s. He describes the key roles of mitochondria in mental health, how certain conditions likely arise from mitochondrial dysfunction, and how low-carbohydrate diets increase mitochondrial turnover to improve mental health. He also explains how low-carbohydrate diets positively impact the gut microbiome and weight loss, important risk factors for mitochondrial health such as marijuana and alcohol, and the best way to increase circulating ketones depending on individual needs. We also cover how a ketogenic diet impacts mood, sleep, and fertility. Dr. Palmer’s work stands as a revolutionary approach to mental health and disease that, given the prevalence of mental health challenges, should be of interest to people of all backgrounds and ages.

For the full show notes, visit hubermanlab.com.