The Effects of Chloride on Renal Perfusion

Chlorine decreases renal perfusion. It's like a signal to the kidney that it has adequate perfusion or maybe even is over perfused. The actual mechanism seems to be related to what I think of as kind of an oft learned but for me a little remembered structure called the macula densa. So if the kidney sees increased sodium and chloride levels in the distal convoluted tubule, the Macula densa will sense that and decrease renal blood flow by inducing renal afferent arterioles vasoconstriction.