The Benefits of Sub-Dissociative Ketamine

If you give a very small dose of ketamine, say 10 milligrams IV in a normal sized, normally perfused adult, then you're going to have almost no psychoproceptual effects. But once you exceed the threshold of dissociation, you don't really get further physiologic effects. And this is where we see the so-called emergence reactions that are unfortunately not that uncommon as someone emerges from procedural sedation.