Improving the Mitochondrial-Microbiome Connection for Optimal Health with Jason Prall
Dr. Jockers Functional Nutrition
Cell Danger Response and Mitochondrial Adaptation
David Jockers and Jason discuss the cell danger response, adaptive oxidative stress, and how mitochondria shift into hypometabolic states.
In this episode, Dr. Jockers explores with Jason Prall how mitochondrial health and the gut microbiome are deeply connected, shaping energy, inflammation, and long-term resilience. You'll learn why mitochondria are far more than energy producers and how their communication drives whole-body health.
In this episode, you'll discover how the microbiome helps translate food into signals that influence mitochondrial function, metabolism, and cellular repair. Jason breaks down why diversity in the gut matters and how everyday choices quietly shape this internal dialogue.
In this episode, you'll hear practical insights on how sleep, light exposure, movement, fasting, and stress act as signals that either strengthen or weaken this mitochondrial–microbiome connection. The conversation leaves space to rethink how small lifestyle shifts can create powerful biological change.
In This Episode:
00:00 Introduction to Human and Mitochondrial DNA
04:06 Deep Dive into Mitochondria and Aging
14:01 Understanding the Gut Microbiome
25:38 Environmental Factors Affecting Health
29:19 Mindfulness and Detoxification
29:55 Impact of Thoughts on Health
31:06 Personalized Health Approaches
31:39 Universal Health Strategies
33:43 Importance of Sleep
37:19 Exercise and Movement
41:07 Fasting and Meal Timing
45:48 Stress and Recovery Balance
48:42 Final Thoughts and Resources
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"Every disease involves mitochondria—when mitochondrial function fails, the body breaks down."
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Resources:
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Connect with Jason Prall:
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Book: https://amzn.to/3YC78Wt
Connect with Dr. Jockers:
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Instagram – https://www.instagram.com/drjockers/
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Facebook – https://www.facebook.com/DrDavidJockers
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YouTube – https://www.youtube.com/user/djockers
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Website – https://drjockers.com/
If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/
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