#33 - Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin
The Peter Attia Drive
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The Effect Size of Genetic Variation on Obesity
The effect size of this genetic variation is not on or off. It just widens, i think, or increases the susceptibility to whatever it is in the environment it's doing this. The animals that we have studied where we've manipulated this gen definitely are sensitive to the environment and will choose or eat more of a high fat diet than a normal one. There are at least half a dozen snips in the first intron n the firstIntron alone. That's where they allas, where they all are. And what is the prevalence in, to the best of our knowledge, of people to day who have at least one of these snips in that t intron, 60 %
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