Overlapping Features of Therapy-Related and Dinovo NPM1 Mutated AML

NPM1 Mutated Acute Myload Leukemia, or AML, is a distinct subtype of leukemia with unique biological and pathological features. It accounts for approximately 30 to 35% of all adult AML cases. Therapy-related NPM1-mutated AML generally confers chemoresistance and a poor prognosis,. However, patients with therapy-related AML who also harbor the NPM1 mutation are rarely associated with 7Q deletion or deletion 7 chromosomal aberrations.