The Effects of Stress on Epigenetic Methylation

Would you want to know when you are going to die?   In this episode of the Biohacking Superhuman Performance podcast, I chat with Hannah Went, Director of Operations at TruDiagnostic, about the stories certain biomarkers can tell about our present health and our future health. From predictors of lifespan to predictors of diseases, there is a large array of biomarkers we can target to help identify a patient’s biological age.    Hannah also shares what lifestyle changes someone can implement to increase their longevity and reverse the clock on their biological age so that it either equals or underpasses a person’s chronological age. From limiting alcohol consumption to caloric restriction, there is a multitude of lifestyle changes one can make to increase their lifespan.    Hannah Went has a lifelong passion for longevity and breakthrough, disruptive technologies that drive radical improvement to the human condition. She attended the University of Kentucky and graduated with a degree in Biology. After graduation, she worked for the International Peptide Society as their Director of Research and Content. Through work in the integrative medicine industry, Hannah saw an opportunity for methylation-based age diagnostics and started TruDiagnostics in 2020. TruDiagnostic is a company focusing on methylation array-based diagnostics for life extension and preventive healthcare serving functional medicine providers.      Thank you to our sponsors for making this episode possible:   Mitopure: Use code NAT10 for 10% off your order at https://www.timelinenutrition.com/shop/nutrition.   LMNT: Use Drinklmnt.com/NAT to get 8 free single serves with any order to try different flavors.   Profound Health: For Oral and Synthetic Bioregulators shipped worldwide as well as cutting edge anti-aging supplements use Profound-Health.com and discount code Longevity15 to save 15% off your first order     Find more from Nathalie:   YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community 2023 Women’s Longevity & Resilience Retreat : Learn More https://www.natniddam.com/longevity-resilience     Find more from Hannah:   Website: everythingepigenetics.com and trudiagnostic.com use code longevity12 for a discount Instagram: https://www.instagram.com/everythingepigenetics and https://www.instagram.com/trudiagnosticofficial      What we discuss:   02:29: What do all of these biomarker tests do? 06:14: What is an R-value? 09:24: What are first-generation clocks looking at? 13:22: What values do the second generation of clocks look at? 14:11: Is the GrimAge indicator an accurate predictor of lifespan? 17:03: What are the different metabolomic and proteomic approaches to biomarkers? 21:43: Why are third-generation clocks better than the precedent ones? 22:43: What can accelerate a person’s biological age? 27:57: Can exercise age you? 28:54: What does telomeres length mean about your health? 34:18: Against what population are your biomarkers usually compared? 36:40: What have the latest clinical studies found? 40:25: In which cases would your clock stay consistent over the years? 43:44: Can we determine which areas in our bodies are aging faster? 47:00: Can caloric restriction reverse biological aging? 52:01: What is the quicksilver protocol? 54:47: How often should you do a TruDiagnostic test? 56:03: What are the top lifestyle hacks to slow chronological aging? 57:30: Which supplements should you take? 58:50: Where to learn more about Hannah     Key takeaways:  

• Three different types of clocks examine biomarkers in terms of longevity: first-generation clocks, second-generation clocks, and third-generation clocks. They all examine different values that are indicative of longevity. Right now, the most precise clock is the third-generation clock as it is trained on direct biomarkers of health and disease, such as grip strength in people, aging-related brain shrinkage, dental health, lung function, and more.

 

• Most of us have a biological age that is more advanced than our chronological age. While some factors influencing this premature aging can’t be changed, our biological age is heavily influenced by our lifestyle. Alcohol consumption, tobacco usage, sleeping patterns, stress management, and exercise are some of the few lifestyle aspects that can reduce our lifespan.