Evolution of Understanding Physiological Responses to Inflammation and Immune Suppression

In this World Shared Practice Forum Podcast, Dr. Mark Hall discusses immunology and inflammation in pediatric sepsis treatment, using immune phenotyping to personalize treatment for pediatric sepsis. LEARNING OBJECTIVES Upon listening to this presentation, learners will be able to: - Recall the history of understanding the inflammatory response in critically ill children - Identify the distinction between the pro-inflammatory response and the immune paralysis phenomenon - Describe the study of immune phenotyping to personalize treatment for pediatric sepsis AUTHORS Mark W. Hall, MD, FAAP, FCCM Chief, Division of Critical Care Medicine Nationwide Children's Hospital Professor in the Department of Pediatrics Division of Critical Care Medicine Nationwide Children's Hospital and The Ohio State University College of Medicine Jeffrey Burns, MD, MPH Chief and Shapiro Chair, Division of Critical Care Medicine; Executive Chair, International Health Services Senior Associate in Critical Care Medicine; Department of Anesthesiology, Critical Care and Pain Medicine Boston Children's Hospital Professor of Anesthesia Harvard Medical School DATES Initial publication: November 27, 2023. ARTICLES REFERENCED 15:48: Cornell TT, Sun L, Hall MW, et al. Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2012;143(5):1160-1166.e1. doi:10.1016/j.jtcvs.2011.09.011 16:10 Collaborative Pediatric Critical Care Research Network, https://www.cpccrn.org/ 17:04 VanBuren JM, Hall M, Zuppa AF, et al. The Design of Nested Adaptive Clinical Trials of Multiple Organ Dysfunction Syndrome Children in a Single Study [published online ahead of print, 2023 Jul 27]. Pediatr Crit Care Med. 2023;10.1097/PCC.0000000000003332. doi:10.1097/PCC.0000000000003332 Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu CITATION Hall MW, O’Hara JE, Burns JP. Immunoparalysis and the Future of Personalized Immunotherapy for Critically Ill Children. 11/2023. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/immunoparalysis-and-the-future-of-personalized-immunotherapy-for-critically-ill-children.