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The Importance of Substitution in Epidemiology
Substitution analysis is a very confusing term because in trials, you can ask people to change what they eat such as reducing the amount of saturated fat. You can also do it from observational studies where you adjust for every other nutrient or food group if you're looking at food substitutions and compare those disease risk associations with their current or baseline intake. We will see more and more of this in the coming years because as you've identified it's such an important question. If we're going to say have less of food eggs, what do we want people to have instead? Really important for that dietary advice.