David A. Sinclair

David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor.

Dr. Sinclair's work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects. In particular, he has examined the role of sirtuins in disease and aging, with special emphasis on how sirtuin activity is modulated by compounds produced by the body as well as those consumed in the diet, such as resveratrol. His work has implications for human metabolism, mitochondrial and neurological health, and cancer.

In this episode, you'll discover:

(00:00) Introduction
(17:59) Caloric restriction, fasting, and exercise activate sirtuin longevity genes
(21:47) Boosting NAD+ levels reduces sirtuin loss with age
(23:03) Resveratrol extends sirtuin activation
(27:36) NAD+ resets epigenetic aging clocks
(31:54) Yamanaka factors reprogram adult cells into stem cells
(46:48) Resveratrol is a xenohormetic compound
(55:35) Resveratrol improved cognitive function in Alzheimer's disease
(58:03) NR and NMN improve cognitive function
(01:06:19) NMN delays aging in multiple organs
(01:01:22) Challenges of translating animal research

If you’re interested in learning more, you can read the full show notes here.

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