Is There a Benefit of Moderating Saturated Fat?

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There is no follow up per se and there's no adjustment for other confounders. So in general, ecological data is hypothesis generating. France has a relatively high intake of saturated fat and their mortality of cardiovascular disease doesn't seem to be super high. But they also have a very high rate of smoking. And yet nobody would accept that as an argument that tobacco doesn't affect cardiovascular disease - it's the same type of argument.

Episode #243. It’s time to face the facts on saturated fat. Dr Gil Carvalho returns to examine a bold new study on this controversial topic, breaking down whether you need to reconsider your food choices in the wake of this study’s release.

We discuss:

Intro (00:00)
Saturated fat misunderstandings: Is saturated fat bad? (17:20)
Principle 1: Dose matters? — How much saturated fat is too much? (22:07)
Is no saturated fat the goal? (30:12)
Principle 2: Replacement nutrient matters (31:54)
Principle 3: Source matters (45:53)
Mechanisms: Saturated fat and heart disease (50:48)
Saturated fats and genetics (55:47)
Target ApoB level (59:40)
Importance of lifetime exposure (1:03:02)
Statins and heart disease risk: Are statins bad for you? (1:08:53)
Mendelian randomization studies (1:10:52)
The totality of evidence (1:15:59)
Saturated fats and total mortality (1:17:46)
Saturated fat and liver health (1:19:51)
Gaps in the research (1:20:43)
Common arguments against lowering saturated fat (1:23:52)
Outro (1:38:36)

To explore more of Dr Gil Carvalho’s work, you can find him on YouTube. You can also connect with him on Twitter and Facebook, and listen to our previous conversation in Episode #207.

Discover more insights and supporting studies in the full show notes.

Enjoy, friends.

Simon

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Simon Hill, MSc, BSc (Hons)

Creator of theproof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

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