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The History of the Plague
The disease doesn't burn out. The outbreaks are short, but if Agrias, who's just a boy when he first gets it, by the time he's writing, it's come back to Antioch for three more times. Archaeological evidence where people have picked up is in the Apestus in various parts of Western Europe, including England. It did reach a quite wide range of rural settings, as well as urban centres. But I think the reach was extensive.