2min chapter

In Our Time: Science cover image

Enzymes

In Our Time: Science

CHAPTER

How to Design an Enzyme

We just don't yet understand enough really to rationally design an enzyme. It would be equivalent to asking somebody from 100 years ago to redesign a computer. I can look for an enzyme that catalyzes a similar reaction, and I can then essentially replicate evolution in a test tube. With the methods we have in the lab these days, you can probably do it in between three to six months, a year if you have a really difficult problem. This is becoming almost routine.

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