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Ep. 49: “Viruses and Aging” Featuring Dr. Clovis Palmer

The Immunology Podcast

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HIV - How Does HIV Screw All That Up at a High Level?

HIV affects immune cells and it causes depletion of CD4 T cells during infection infected individuals. So I curiously thought that one of the reasons could be that these immune cells are unable to take up sufficient nutrients like glucose, therefore they would dive. In fact, we found that HIV infection actually causes immune cells to take up more glucose because in order to maintain their activated state, they need more energy. And so that's what we basically found is that in the context of HIV, there's increased glucose uptake but less oxidative phosphorylation.

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