1.3 to 1.9 - I'm Not Reversing Someone With Two Less Than or Equal to 1.3

American Stroke Association released new guidelines on warfarin and factor 10a inhibitors. Nia: The wording was okay, they said it may be reasonable to give PCC for 1.3-1.9 INR reversal. But the implication is that if dexanethal isn't available then you have to use PCC. Casey: I think their reading of the literature is very vague on the goodness of indexing an alpha. In fact, there's a lot of intimation of reversal of the reversal,. You know, this rebound effect. It's really tough now to go against guidelines like the American Stroke Association.