Is it because you hit the immune om beat it down, and then it comes back stronger? Very good question. So i don't know the answer that that could be one mechanism where cycling it is what's creating an immune response. It could also be that it that you're hitting a certain subset of the immune cell at this lower infrequent so there are these cells called tea cells. And maybe the dose of m the dose o rapamisen that we were giving patients back on the transplant ward just indiscriminately whacked tea cells.