The Role of Biotin in Oxaloacetate Decarboxylation

In a 2018 paper, the authors attempted to explain the bifunctionality of a quote human oxaloacetate decarboxylase known as fumeral acetoacetate hydrolyse. This enzyme will cleave fumeral pyruvate into fumarate and pyruVate yet will also decarboxyate oxaloacette to form pyruvates. The trend is that there is a general trend thatOxaloacetate metabolizing enzymes bind oxaloade even more strongly which suggests it would be decarboxymated to formate. So what do we establish now? Pyruvate carboxylase can run backwards to dec