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Prefusion Stabilization Increases Immune Response
The two mutations used for prefusion stabilization had originally been developed during efforts to develop vaccines for earlier coronovirises such as h k one, mers and sars. In the context of the sars virus, the prefusion stabilized spike protein bound to two slightly more strongly than the natural spike. The binding strength reported for the fizer acine is stronger than that reported for the natural stars cob two virus. But let's consider the two things that might impact the toxicity based on what we know so far. One shedding increases toxicity and may be necessary for it, while the roll of ac two binding is unclear.