Deafness and Loop Diuretics

I've only seen ototoxicity once, and that was with a very rapid IV administration similar to what JC was saying. That's smack heart failure study I talked about yesterday, was two, two 50s twice a day. And it's difficult to do, because you can't placebo control these patients because they can't breathe. They have to get loop diuretics. But it is a concerning finding, right? They look at all these other markers that we're trying to suppress in heart failure and to, testosterone all these things go up when you give the loop diuretic. So on one hand how on one hand do you say we need to use as inhibitors Mineral quarter sector