Challenges of Identifying Schizophrenia and the Role of Biomarkers

Up to 80% of people with schizophrenia aren't aware they're experiencing early schizophrenia symptoms. Most people with schizophrenia go through a prodromal stage, where there's subtle changes in mood, thinking, and behavior. It's an evolution of the symptoms to come.

Early indicators vary based on the age they start. An adult who develops schizophrenia will experience different signs than a child who develops the condition.

Host Rachel Star Withers and cohost Gabe Howard explore the early signs of schizophrenia in children, teens, and adults.

Joining to discuss the future of identifying biomarkers for schizophrenia is Carlos Larrauri, a psychiatric mental health nurse practitioner who also lives with schizophrenia. Mr. Larrauri co-chairs the steering committee for the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ), which is working to identify early indicators of schizophrenia.

To learn more about the research AMP SCZ is undertaking, please visit www.ampscz.org.

To learn more -- or read the transcript -- please visit the official episode page.

Our guest, Carlos A. Larrauri, MSN, is co-chair of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) and has formerly served on the National Alliance on Mental Illness (NAMI) and NAMI Miami-Dade County Board of Directors. Diagnosed with schizophrenia at 23 years old, access to quality mental health care, community-based treatment, and early intervention afforded him the best opportunity for recovery.

Mr. Larrauri is pursuing a law degree at the University of Michigan Law School and a concurrent master in public administration at the Harvard Kennedy School, where he was Zuckerman Fellow at Harvard’s Center for Public Leadership. He’s board certified as a family nurse practitioner and psychiatric mental health nurse practitioner and formerly lectured at the University of Miami and Miami Dade College.

Mr. Larrauri aspires to interface advocacy and research to reduce health inequities for people living with mental illness. To learn more about Carlos and his work, visit his website or his LinkedIn.

The Accelerating Medicines Partnership® (AMP®) program—Schizophrenia (SCZ) is a public-private partnership between the National Institute of Mental Health (NIMH), the U.S. Food and Drug Administration (FDA), the European Medicines Agency, and multiple public and private organizations.

Launched in 2020 and managed by the Foundation for the National Institutes of Health, the AMP SCZ program addresses the critical need for more effective treatments for people with schizophrenia and related mental health conditions.

The overarching aim is to improve our understanding of disease pathways and identify new and better targets for treatment.

Our host, Rachel Star Withers, creates videos documenting her schizophrenia, ways to manage and let others like her know they are not alone and can still live an amazing life. She has written Lil Broken Star: Understanding Schizophrenia for Kids and a tool for schizophrenics, To See in the Dark: Hallucination and Delusion Journal. Fun Fact: She has wrestled alligators.

To learn more about Rachel, please visit her website, RachelStarLive.com.

Our cohost, Gabe Howard, is an award-winning writer and speaker who lives with bipolar disorder. He is the author of the popular book, "Mental Illness is an Asshole and other Observations," available from Amazon; signed copies are also available directly from the author.

Gabe makes his home in the suburbs of Columbus, Ohio. He lives with his supportive wife, Kendall, and a Miniature Schnauzer dog that he never wanted, but now can’t imagine life without. To learn more about Gabe, please visit his website, gabehoward.com.

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