Do You Use Lorlatanate in Brain Metastasies?

The presence of brain metastasies doesn't push me to Lorlatanib when we go through the real-life cases I tried really hard to think of one situation where I would absolutely start with Lorlatan Tib. Ben says his dose reduction rate is 50 percent as opposed to 20 percent in the trial and so you know there's more toxicity going on than was captured in that paper.