Rheumatic Heart Disease and Mitral Valve

A study from 2009 found that the serum, the sera of patients from rheumatic heart disease contained antibodies that bound specifically to the part of type four collagen that M protein binds. And so then the next step would maybe be that this sort of common M protein collagen has an antibody that's generated against it. So we've got pretty good histological data for all of that. We know that these cause valvular dysfunction and eventually sort of mixed with stenosis.