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Insulin Resistance
There's this debate that at least I've caught wind of within the nutrition community as to what creates the conditions of insulin resistance. Irrespective of where that energy comes from, it creates this sort of energy toxicity scenario on the body, which drives insulin resistance. If we're not talking about a diabetic person, fat consumption alone has no effect on insulin. That immediately blows the whole thing apart because any time energy comes down, it's going to depress insulin.