iwNHL 2021: immunotherapy and the microenvironment
VJHemOnc Podcast
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Factors influencing response to T-cell therapy in lymphoma patients
This chapter explores the factors that contribute to the response of T-cell therapy in lymphoma patients, including combination approaches, lymphoma microenvironment, tumor size, expansion of CAR T-cells, inflammatory markers, and suppressive myeloid cells. It discusses the association between interferon-stimulated gene expression profile, driver mutations, and outcomes in DLBCL patients. The chapter emphasizes the need for larger data sets and in vivo models to better understand CAR T-cell expansion and the impact of the tumor microenvironment.
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