Exploring the Multifaceted Nature of Gut-Brain Neuromodulators and Probiotics in IBS Treatment

Irritable bowel syndrome (IBS) is often diagnosed when symptoms don’t have an obvious cause. But anyone with IBS symptoms knows it’s a REAL condition. Dr. Alex Ford and I are share what irritable bowel syndrome treatments are getting wrong—and how to start feeling better. 

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Timestamps

00:00 Intro 

04:40 What is IBS?

12:00 The problem with restrictive diets

14:35 Prevalence of SIBO in IBS patients

21:06 The gut-brain connection 

25:25 Antidepressant effects on the gut

33:30 Do probiotics work for IBS?

40:28 IBS symptoms

47:06 Treatment options

Featured Studies 

Ford’s Research

📉Efficacy of Probiotics in IBS: https://pubmed.ncbi.nlm.nih.gov/37541528/  

📉Antibiotics and Probiotics for IBS: https://pubmed.ncbi.nlm.nih.gov/37184752/ 

📉Amitriptyline at Low-Dose and Titrated for IBS as Second-Line Treatment in primary care: https://pubmed.ncbi.nlm.nih.gov/37858323/  

📉Disorders of gut-brain interaction: https://pubmed.ncbi.nlm.nih.gov/35781806/  

📉Rome IV Criteria: https://theromefoundation.org/rome-iv/rome-iv-criteria/  

📉Global prevalence of IBS according to Rome III or IV criteria: https://pubmed.ncbi.nlm.nih.gov/32702295/  

📉IBS and the Gut Microbiome: A Review: https://pubmed.ncbi.nlm.nih.gov/37048642/  

📉Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression: https://pubmed.ncbi.nlm.nih.gov/24853043/  

📉Interactions between symptoms and psychological status in IBS: https://pubmed.ncbi.nlm.nih.gov/36178333/ 

📉Probiotics fortify intestinal barrier function: https://pubmed.ncbi.nlm.nih.gov/37168869/ 

📉Probiotics for Preventing and Treating SIBO: https://pubmed.ncbi.nlm.nih.gov/28267052/ 

📉The effects of probiotics on constipation in adults: https://pubmed.ncbi.nlm.nih.gov/32005532/ 

📉The effect of multistrain probiotics on constipation in the elderly: https://pubmed.ncbi.nlm.nih.gov/35927504/ 

📉Efficacy of probiotics, prebiotics and synbiotics in IBS: https://pubmed.ncbi.nlm.nih.gov/37772692/  

📉Outcome-Specific Efficacy of Different Probiotic Strains in IBS: https://pubmed.ncbi.nlm.nih.gov/37686889/ 

📉Strain-specific and outcome-specific efficacy of probiotics for IBS: https://pubmed.ncbi.nlm.nih.gov/34712929/  

📉Efficacy of probiotics, prebiotics and synbiotics in IBS: https://pubmed.ncbi.nlm.nih.gov/37772692/  

📉Efficacy of a low FODMAP diet in IBS: https://pubmed.ncbi.nlm.nih.gov/34376515/  

📉Dietary glutamine supplements for post infectious IBS: https://pubmed.ncbi.nlm.nih.gov/30108163/ 

📉Peppermint oil for IBS: https://pubmed.ncbi.nlm.nih.gov/24100754/ 

📉Efficacy and Safety of Peppermint Oil in [...] Patients With IBS: https://pubmed.ncbi.nlm.nih.gov/31470006/ 

📉The IBS Outcome Study (IBSOS): https://pubmed.ncbi.nlm.nih.gov/22846389/  

📉Treatments for diarrhea-predominant IBS: https://pubmed.ncbi.nlm.nih.gov/30194692/  

📉Comparing probiotic and drug interventions in IBS:  https://pubmed.ncbi.nlm.nih.gov/35848115/  

📉Probiotics, prebiotics, and low FODMAP diet for IBS: https://pubmed.ncbi.nlm.nih.gov/30935559/  

📉Anti-inflammatory effect of amitriptyline in a rat model of acetic acid-induced colitis: the involvement of the TLR4/NF-kB signaling pathway: https://pubmed.ncbi.nlm.nih.gov/33336463/  

📉An Investigation on in vitro and in vivo Antimicrobial Properties of the Antidepressant: Amitriptyline Hydrochloride: https://pubmed.ncbi.nlm.nih.gov/24031539/  

📉Amitriptyline modifies the visceral hypersensitivity response to acute stress in the IBS: https://pubmed.ncbi.nlm.nih.gov/19076934/  

📉Effect of a tricyclic antidepressant on small intestinal motility in health and diarrhea-predominant IBS: https://pubmed.ncbi.nlm.nih.gov/7821126/  

📉Recurrence of depression after discontinuation of long-term amitriptyline treatment: https://pubmed.ncbi.nlm.nih.gov/6800270/  

📉Long-term amitriptyline in chronic depression: https://pubmed.ncbi.nlm.nih.gov/3894196/  

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DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.

Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g 

*Full transcript available on YouTube by clicking the “Show transcript” button on the bottom right of the video.