The Importance of Insulin Resistance

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The body has a remarkable capacity to satisfy the nutritional needs for glucose, while still maintaining a good stable level of glucose in the blood. Just four grams of glucose circulates in the average 70 kilo person. That is a ludicrously small amount to keep tightly regulated in your bloodstream. I would liken it to acid base balance. Within medicine, you have a very tightly regulated pH of your blood between 7.35 and 7.45 outside of those areas.

In today’s solo episode and I’ll be talking about insulin resistance, how this impacts your risk of disease and why insulin resistance could drive many chronic conditions and why certain lifestyle measures work for improving metabolic health.

By the end of the episode you will understand:

The relationship between IR and disease

The importance of sugar balance in the body

What insulin is and how insulin works

What happens when we become resistant to insulin

What are the causes of IR

What we can do to become more insulin sensitive and ultimately prevent disease

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References:

4 grams of glucose - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636990/

IR Overview - https://www.ncbi.nlm.nih.gov/books/NBK507839/

Insulin resistance Mechanisms - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831809/

Insulin resistance, genes and mitochondria - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341556/

Obesity Insulin and cancer - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214048/

Insulin resistance from euglycaemic clamps - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379600/

Sleep debt and Insulin resistance - https://pubmed.ncbi.nlm.nih.gov/10543671/

Increased snacking with poor sleep - https://pubmed.ncbi.nlm.nih.gov/19056602/