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Johnny Anidis is the CF Renborg Chair in Disease Prevention at Stanford University. His 2005 paper from PLOS Medicine, Why Most Published Research Findings Are False, has been the most accessed article in the history of PLOS with 2.5 million hits. He claims or perhaps concedes that he loves to be constantly reminded that he knows next to nothing.

John Ioannidis of Stanford University talks with EconTalk host Russ Roberts about his research on the reliability of published research findings. They discuss Ioannidis's recent study on bias in economics research, meta-analysis, the challenge of small sample analysis, and the reliability of statistical significance as a measure of success in empirical research.