This chapter explores the genetic lineage and selective breeding of various dog breeds, including the Tibetan Mastiff and bulldog, while drawing connections to their wolf ancestors. It also delves into the fascinating capabilities of human olfaction, comparing it to scent hounds, and highlights the complexities of scent perception, health implications, and the emotional bonds that exist between humans and dogs. Throughout the discussion, ethical considerations regarding dog breeding and fights, alongside potential treatments for olfactory loss, further enrich the narrative.